2/28/2023 0 Comments Uvm insomnia help![]() Crude probability of cardiovascular death was higher among rural MDS patients. ![]() MDS incidence was equal in urban and rural populations (6.7 per 100,000). Cox regression estimated the association of rurality and cardiovascular death. Rurality was defined using Rural-Urban Continuum Codes. Surveillance, Epidemiology, and End Results (SEER) registry, we identified 52,750 MDS patients between 20. Rurality is associated with increased CVD but studies on cardiovascular geographic disparities in MDS are lacking. These results support additional larger, randomized controlled trials of Alpha-Stim® for veterans with PTSD.Ĭlonal hematopoiesis, a precursor to myelodysplastic syndromes (MDS), constitutes a novel cardiovascular disease (CVD) risk factor, causing growing interest in cardiovascular outcomes in MDS. Limitations of this pilot study include the open-label, uncontrolled design and small sample size. The results suggest preliminary efficacy for improving PTSD symptoms as well as concomitant depression symptoms, insomnia, and pain. Presumptive loss of diagnosis rates (i.e., PTSD Checklist for DSM-5 total score below 33) immediately following treatment and one and three months later were 43%, 33%, and 29%, respectively.Īlpha-Stim® showed an excellent safety profile with no adverse effects. ![]() Significant improvements in PTSD and depression, but not pain, persisted at one-month and three-months posttreatment. Following four weeks of Alpha-Stim® treatment, PTSD symptoms decreased by 38%, depression symptoms decreased by 52%, insomnia decreased by 34%, and pain decreased by 11%. Seven patients (78%) successfully completed treatment. Effects on PTSD symptoms, depression symptoms, and pain were assessed one month and three months post-treatment. Effects on PTSD symptoms, functioning, depression symptoms, pain, anxiety symptoms, and insomnia were assessed at baseline and every week of treatment for four weeks. Treatment consisted of 20 CES sessions administered at home over 40 days. Open-label Alpha-Stim® was administered to nine veterans who were diagnosed with PTSD via structured interview (Clinician-Administered PTSD Scale for DSM-5 ) and were taking at least one psychotropic medication. The objective of this open-label pilot study was to examine feasibility, safety, and preliminary efficacy of Alpha-Stim® for treatment of PTSD. However, CES has not yet been specifically tested as a treatment for PTSD. Cranial electrotherapy stimulation (CES) techniques, such as Alpha-Stim®, have demonstrated preliminary benefit for symptoms that commonly co-occur with PTSD, such as pain, anxiety, depression, and insomnia. Neuromodulation of brain circuits important for affect, behavior, and cognition may decrease the symptomatology and functional impairment of military veterans suffering from posttraumatic stress disorder (PTSD).
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